Depression is a leading cause of disability worldwide and quickly becoming a global health priority. Depression can lead to suicide; however, suicide, itself, is likely preventable. In the United States, more than 90 percent of people who die by suicide have a mental disorder, usually depression. In this workshop, you receive an update on evidence-based strategies in the assessment and treatment of depression and suicide. Focus on recognizing depression and suicide probability in high-risk groups; variability in clinical presentations; and cognitive, behavioral and emotion-focused strategies to reduce severity, risk and, ultimately, suffering.